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Citing and Credits

In citing the ConSurf-DB server please refer to:

2. Goldenberg O., Erez E., Nimrod G., Ben-Tal N. 2009.
The ConSurf-DB: Pre-calculated evolutionary conservation profiles of protein structures.
Nucleic Acids Research, 2009, Vol. 37, Database issue D323-D327 PDF Online version

Main References

  • Mayrose I., Graur D., Ben-Tal N. and Pupko T. 2004. Comparison of site-specific rate-inference methods for protein sequences: empirical Bayesian methods are superior. Mol. Biol. Evol. 21:1781-1791. PDF
  • Pupko T., Bell R.E., Mayrose I., Glaser F. and Ben-Tal N. 2002. Rate4Site: an algorithmic tool for the identification of functional regions in proteins by surface mapping of evolutionary determinants within their homologues. Bioinformatics 18 Suppl 1:S71-S77. PDF
  • Armon A., Graur D. and Ben-Tal N. 2001. ConSurf: An Algorithmic Tool for the Identification of Functional Regions in Proteins by Surface-Mapping of Phylogenetic Information. J. Mol. Biol. 307:447-463. PDF
  • Martz E. 2005. FirstGlance in Jmol (
  • Martz E. 2002. Protein Explorer: easy yet powerful macromolecular visualization. Trends in Biochemical Sciences.27:107-109. (PDF available on request.)
  • Pettersen, E.F., Goddard, T.D., Huang, C.C., Couch, G.S., Greenblatt, D.M., Meng, E.C., and Ferrin, T.E. UCSF Chimera - A Visualization System for Exploratory Research and Analysis. J. Comput. Chem. 25(13):1605-1612 (2004).
  • Landau, M., Mayrose, I., Rosenberg, Y., Glaser, F., Martz, E., Pupko, T. and Ben-Tal, N. (2005) ConSurf 2005: the projection of evolutionary conservation scores of residues on protein structures. Nucleic acids research, 33, W299-302.
  • Glaser, F., Rosenberg, Y., Kessel, A., Pupko, T. and Ben-Tal, N. (2005) The ConSurf-HSSP database: the mapping of evolutionary conservation among homologs onto PDB structures. Proteins, 58, 610-617.


  • We are grateful to the Bioinformatics Unit at the George S. Wise Faculty of Life Sciences and the Blavatnik School of Computer Science at Tel Aviv University for providing technical assistance and computation facilities.
  • We thank Eric Martz for his constant feedback on the various ConSurf tools. This feedback was reflected in the design of ConSurf-DB.
  • This research was funded within DIP project.
  • The development was funded in part by Edmond J. Safra Center for Bioinformatics at Tel-Aviv university.